The effect of cyproheptadine hydrochloride (periactin) and ... | 藥品回收網

由MCouluris著作·2008·被引用88次—Theeffectofcyproheptadinehydrochloride(periactin)andmegestrolacetate(​megace)onweightinchildrenwithcancer/treatment-relatedcachexia.JPediatr ...

Background: Children with cancer frequently have associated cachexia and malnutrition. Failure to thrive affects nearly 40% of oncology patients with advanced or progressive disease. Malnutrition can erode quality of life and adversely impact disease prognosis. Appetite stimulation and increased food intake is 1 approach to combat cancer-related cachexia.

Materials and methods: Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss. All participants started CH and were evaluated for response after 4 weeks. Efficacy of megestrol acetate (MA) was evaluated in patients who did not respond to CH. Medical evaluation, weight measurements, prealbumin, and serum leptin levels were preformed at follo...